A study research assistant chooses a numbered envelope in sequential order from the correct stratum.
Once the correct stratum is established at baseline, the patient is given the subsequent unique four-digit randomisation number from his/her stratum on the randomisation list.
If the baseline questionnaire is completed, each employee can choose one of the two succeeding envelopes of the correct stratum provided by the researcher.
However, some less experienced basic health staff (BHS) did encounter difficulties in the stratification process and were not clear about some of the key terms and definitions which are important for determining the correct stratum for each village.
After informed consent and completing the baseline questionnaire, the temporary agency worker or unemployed worker is asked to choose one of the two succeeding envelopes of the correct stratum.
If the interviewer found that a child fell outside of his/her expected age stratum but nonetheless remained ≤ 59 months of age, the survey was completed, and the child was assigned to the correct age stratum.
Our results suggested that the arrested development of keratinocytes in progeroid epidermis might have caused a failure to maintain correct hydration of the stratum corneum and a failure to form a functional lipid matrix in the stratum corneum intracellular space (Lee et al., 2006).
Filaggrin monomer is required for keratin bundle formation and correct biogenesis of the stratum corneum, and its degradation and modification to form natural moisturizing factors in the stratum corneum is essential for maintaining epidermal hydration [44].
A cautious approach would therefore be to treat these results as exploratory and look for further opportunities to confirm them in other settings, perhaps using historical benchmarking data derived from a comparable population (matched within strata) and corrected for secular trends.
This variability may be due to differences in eco-epidemiological strata in Ethiopia, correct knowledge regarding the route of malaria transmission, perceptions of malaria and ITN use, and access to malaria-related health services.
