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If error correction and the spindle checkpoint were molecularly distinct, then the inhibition of error correction should only influence the ability to correct improper attachments, but not the checkpoint response, as predicted for the test of model 1.
The El Paso Corporation, the pipeline operator, said yesterday that its book value would fall by $2.4 billion as it restates reports dating to 1999 to correct improper accounting for energy reserves and contracts.
Furthermore, Aurora B activity at centromeres, which is needed to correct improper microtubule attachments, is partially reduced upon condensin dysfunction.
In addition to attaching the microtubules to the chromosomes, the kinetochores also correct improper attachments and move the chromosomes along microtubules.
However, this may be a consequence of residual kinase activity on incomplete depletion or inactivation of Aurora B. As the ability of Aurora B to correct improper attachments may rely on increased distance from its kinetochore substrates, it is logical to ask whether its function in the SAC is regulated in the same manner.
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The resultant dispersed microtubule attachment sites produce excessive merotelic attachments and partial depletion at centromeres of the Aurora B activity that is needed to correct these improper attachments (Fig. 8B).
The fourth module discerns correct from improper attachments, preventing the stabilization of the latter and allowing the selective stabilization of the former.
The news jolted an already disbelieving marketplace: Correcting the improper accounting for its dealings with Fastow partnerships since 1997, Enron reported, meant $600 million in previously reported profits were wiped out.
The next split on variable Al corrects the improper assignment of one sample and it is of a lower importance.
Importantly, numerous studies revealed that Aurora B is concentrated at the centromere in prometaphase and metaphase [65] and interaction with mitotic centromere-associated kinesin (MCAK) is important for proper chromosome biorientation and for correcting or preventing improper microtubule-kinetochore attachments in mammalian cells [66], [67], [68], [69].
For example, Pathview Parser corrects for the improper KEGG definition of enzyme-compound interactions by merging and resolving the conflicting ECrel record and associated reactions records (Supplementary Fig. S2).
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