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This answer has been updated to correct a point about reader-submitted photos.
These constructs were evaluated for their ability to correct a point mutation in the gene encoding recombinant enhanced green fluorescent protein (eGFP) that rendered the protein nonfluorescent.
EDIT-101 is designed to correct a point mutation in the CEP290 gene, the IVS26 mutation, that leads to incorrect splicing of the CPE290 transcript and a dysfunctional CEP290 protein.
Traditionally, if researchers want to correct a point mutation within a gene, they would also deliver an additional piece of DNA to the cells.
In another study, they were able to use zinc finger nucleases (ZFNs) and PiggyBac technology in human iPS cells to correct a point mutation (Glu342Lys) in the α1-antitrypsin gene that is responsible for α1-antitrypsin deficiency (Yusa et al. 2011).
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"The F.D.A. wants us to correct a few points in those ads".
To genetically correct a disease-causing point mutation in human induced pluripotent stem cells (iPSCs) derived from a hemophilia B patient.
By Bill Franzen May 10 , 2013Luke Barry has asked the Laramie Times to correct a number of points in a write-up of him published April 2 , 1873
Luke Barry has asked the Laramie Times to correct a number of points in a write-up of him published April 2 , 1873
Could I correct a couple of points in Polly Toynbee's extraordinarily mendacious article about the Daily Mail (Bully-in-chief Dacre is off. Good riddance, 8 June).
These technologies hold the promise of targeted gene correction in human induced pluripotent stem cells, as has been recently demonstrated for correcting a biallelic point mutation in α-1-antitrypsin, which in man causes a deficiency which leads to emphysema [ 18].
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