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Over 50 days, we compared the survival of ants in colonies that were free to remove corpses with those that were restricted in their corpse removal.
"I really enjoyed doing it," she recalled of that first corpse removal, in 1996.
Allowing for corpse removal by scavengers, an estimated 70% of red grouse and 29% of black grouse collisions were fatal.
These results indicate that misc-1 RNAi does not impair the mechanism of cell corpse removal.
To date, all engulfment genes identified in the nematode context have also played an evolutionarily conserved role in corpse removal [29] [31].
Genetically, we show that LST-4 functions at the same step as DYN-1 during corpse removal, upstream of the GTPase RAB-5.
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These results suggest that among the clathrin adaptors examined, EPN-1 is uniquely involved in cell-corpse removal in embryos.
By contrast, frequent delays in cell-corpse removal were observed from chc-1 RNAi) chc-1 RNAiupplembryosy material Fig. supplementary
Interestingly, inactivating AP-1, AP-2 or AP-3 complex subunits or epn-1 failed to affect germ cell-corpse removal (supplementary material Fig. S3B).
These observations indicate that the Ced phenotype observed in chc-1 RNAi) chc-1 RNAi canimalsy ispairing causedorpse removal rather than excessive cell deaths.
Inactivating each of the AP2 subunits APA-2, APB-1, DPY-23 or APS-2 individually is known to impair endocytosis (Grant and Hirsh, 1999; Gu et al., 2008; Gu et al., 2013), but not cell-corpse removal (Fig. 2A).
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