However, after divided subjects into the control and DM group, HbA1c was not significantly associated with any coronary function parameters, either in control group or in DM group.
The resulting in vivo adiposity-related changes in coronary function could be retained ex vivo and contribute to the adaptation of myocardial function in nascent obesity.
For example, epicardial and perivascular fat may play a role in modulating coronary function and pathophysiology, providing a potential mechanism to link double diabetes with CVD.
Tawakol A, Migrino RQ, Aziz KS, Waitkowska J, Holmvang G, Alpert NM, Muller JE, Fischman AJ, Gewirtz H. High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease.
These human findings are in accordance with the animal data, and suggest that the presence of AF induces abnormalities in microvascular coronary function that are at least partially reversible with restoration of SR.
The current study demonstrates for the first time that glycaemic control is not an independent predictor of a better coronary microvascular function in T2DM patients with chest pain and non-obstructive coronary angiogram.
CFR, the ratio of hyperemic to basal coronary blood flow velocity, is a physiological parameter that reflects coronary microvascular function in the absence of large vessel stenosis [ 16], and many reports have described the utility of measuring CFR by noninvasive transthoracic Doppler echocardiography in various diseases including diabetes [ 17– 217.
This study sought to examine the relationship between inflammation and coronary microvascular function in asymptomatic individuals using positron emission tomography (PET) and assessment of coronary flow reserve (CFR).
The main findings of this study are (1) a greater cardiac adipose volume is independently associated with an increase in LVM, (2) EAT is not predictive of coronary microvascular function in symptomatic subjects without obstructive CAD and (3) LVM is associated with coronary microvascular function independently of traditional risk factors and EAT volume.
Basal coronary endothelial function in diabetic rats was maintained at 3 weeks post induction, however there are reports from experiments in isolated coronary arteries suggesting that by 4 weeks, endothelium-dependent vasodilation is impaired [ 27, 28].
