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This study was designed to evaluate outcome of hypertensive patients on the basis of their epicardial coronary function assessed by cold pressor test (CPT).
In conclusion, this study have proven that diosgenin have enough potential to improve the coronary function and interfere the osteochondrogenic transdifferentiation program of aortic VSMC which supports its antivascular calcification potential.
An efficient and effective way of stressing coronary function in this setting is with the use of vasodilators.
For example, epicardial and perivascular fat may play a role in modulating coronary function and pathophysiology, providing a potential mechanism to link double diabetes with CVD.
The resulting in vivo adiposity-related changes in coronary function could be retained ex vivo and contribute to the adaptation of myocardial function in nascent obesity.
However, after divided subjects into the control and DM group, HbA1c was not significantly associated with any coronary function parameters, either in control group or in DM group.
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However, there are limited data on the direct relationship of coronary microvascular function with LV diastolic function in patients with diabetes.
Furthermore, we have shown in vivo, that in early-diabetic rats increased ROCK activity plays a role in coronary microvasculature function, as acute ROCK inhibition increased coronary perfusion.
Therefore we aimed to ascertain whether an increase in ROCK activity plays a role in the deterioration of coronary vascular function in early stage diabetes.
This study therefore aimed to ascertain whether ROCK plays a role in the deterioration of coronary vascular function in early stage diabetes.
Although our results fill an important gap in the earlier published data, the association between coronary microvascular function and LV diastolic dysfunction does not prove that coronary microvascular function is the cause of LV diastolic dysfunction in patients with diabetes.
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