Sentence examples for coronary dysfunction in from inspiring English sources
We speculate that the reduction of CSE, concomitant with reduced HO-1 and eNOS, and coinciding with enhanced oxidative/nitrosative stress may contribute to the development of coronary dysfunction in sepsis.
This study has demonstrated a widespread involvement of the ROCK signalling pathway in early stage diabetic coronary dysfunction in vivo.
One such potential mechanism is impaired myocardial perfusion and perfusion reserve due to microvascular coronary dysfunction in the presence of AF.
Acute Rho-kinase inhibition improves coronary dysfunction in vivo in the early diabetic microcirculation [ 63], while long-term Rho-kinase inhibition ameliorates myocardial hypertrophy, apoptosis, fibrosis, and subsequent cardiac remodeling in diabetes [ 64].
Thus there may be a role for ROCK in the early diabetic coronary dysfunction we have previously described [ 6].
Most patients underwent a non-invasive test for detection of ischemia, however a positive result was not an inclusion criteria in our study since a negative non-invasive stress test does not rule out coronary vasomotor dysfunction in symptomatic patients with nonobstructive coronary artery disease [ 10].
Previous studies have demonstrated persistent coronary arterial dysfunction in patients with persistent and regressed coronary aneurysm [ 3- 5].
Furthermore, two patients in this study also developed sympathetic denervation without myocardial perfusion abnormalities, which may suggest (not yet detectable) microvascular coronary dysfunction.
Hasdai et al. reported that coronary endothelial dysfunction in humans may cause dysfunction of microcirculation endothelium of the coronary territory, which results in reduction of myocardial blood flow [ 29].
Salbutamol-stress [11C]acetate micro-PET imaging of EFRNOM may be suitable for assessment of coronary endothelial dysfunction in small animal models of disease and evaluation of new therapies.
Therefore, we speculated that ERT could ameliorate coronary microvascular dysfunction in FD through these two mechanisms.
