DOI: http://dx.doi.org/10.7554/eLife.04236.013 A cornerstone of mechanisms regulating transcription is the productive encounter of one or more TFs with their cognate binding sites to form specific protein:DNA complexes that controls the transcriptional output of a gene.
Nevertheless, inflammation is growingly considered as a cornerstone of the mechanisms underlying the aging process, so to even generate the neologism "inflamm-aging" (Franceschi et al 2000a).
Discovery of a large number of conserved non-coding elements (CNEs) in vertebrate genomes provides a cornerstone to elucidate molecular mechanisms of macroevolution.
This compound also contains a methyl group at position R5 on ring A. The presence of the core structure common to all the compounds in this group suggests that it may play a cornerstone role in the mechanism of action for this cohort of compounds.
By applying HER as a test reaction, which is also considered as a cornerstone to explore the mechanism of other multielectron transfer processes, we expect that this study will largely expand the spectrum of catalysts for other energy-related electrocatalytic reactions.
A clear understanding of distress mechanisms is the cornerstone for extending pavement service life.
The researcher, based on the preferential framework derived out of this current study, envisions the creation of a predictive model that used the outputs of this current framework as a cornerstone for the said predictive mechanism.
The use of a random mechanism is the cornerstone of these trials and is the basis for statistical theory and analysis of these trials (Greenland, 1990).
Identifying causal mechanisms has become a cornerstone of experimental social psychology, and editors in top social psychology journals champion the use of mediation methods, particularly innovative ones when possible (e.g. Halberstadt, 2010, Smith, 2012).
The most recent advances on EC reactor modeling are summarized with special emphasis on four major issues that still constitute the cornerstone of EC: the theoretical understanding of mechanisms governing pollution abatement, modeling approaches, CFD simulations, and techno-economic optimization.
