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The researchers designed the particles to carry the drugs in their hydrophobic cores, bound to a polymer known as PLGA, which is used in many other drug delivery particles and medical devices.
We are extending this strategy toward the development of protein-detecting devices and are exploring the magnetic properties of Fe cores bound to specific areas on Si wafers.
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The crystal structures of three group I introns solved at moderately high resolution (3.1 3.8 Å) reveal a remarkably conserved catalytic core bound to the metal ions required for activity.
Nevertheless, we observed that the Core bound to CHMP4b, whereas NS5A did not (Fig. 4D), suggesting that the Core has a novel motif required for the HCV production.
(A ) The unlocked conformation of AP-2 core bound to myristoylated Nef (orange).
The closed-state helicase core bound to ssRNA and ATP represents the 'post-unwound' state of the enzyme.
To define the position of eIF3 on 40S, we prepared and crosslinked samples of the yeast eIF3 core bound to 40S⋅eIF1.
The structure of the E2 core bound to a broadly neutralizing antibody was first crystalized at 2.65 angstroms [ 10], and deposited in PDB [ 19] database (PDB ID: 4MWF).
Due to technical challenges in the structural characterization of the nucleosome core bound to chromatin factors, much less is understood regarding the molecular recognition of the disk surfaces of the histone octamer and nucleosomal DNA.
Recently, the crystal structure of E2 core bound to neutralizing antibody AR3C has been crystalized [ 10], The antibody AR3C belongs to a group of broadly neutralizing antibodies that recognize antigenic region 3 (AR3) of E2 protein and cross-neutralizes HCV genotypes by blocking CD81 receptor binding site [ 14].
Specifically, ECMs in bone have many protein fibers (e.g., collagen fibers and elastin fibers) and proteoglycans consisting of a protein core covalently bound to long chains of sulfated glycosaminoglycan [GAG] disaccharides (e.g., chondroitin sulfate and hyaluronic acid).
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CEO of Professional Science Editing for Scientists @ prosciediting.com