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These may represent cases of miRNA and mRNA coregulation in the brain that are conserved in mammalian species, and should therefore be considered high priority targets for future studies.
Because the r-protein mRNAs were reliably expressed and showed robust cotranslation among themselves and between rpl24b and eif3h mutants, we characterized their translational coregulation in greater detail.
However, the strong coregulation in the abundance of lipid species identified in this study necessitated a more global analysis of potential lipid function.
Besides the expected topological connections, the topologically unconnected reactions in a CoSet may indicate the information of transcriptional coregulation in MN.
This result shows that increase in variability does not imply deregulation, but in fact it probably means a gain of coregulation in the diseased samples.
The PCC values were determined for the unpaired, the paired but not adjacent, and the adjacent RRB gene pairs across these conditions, and we observed elevated levels of coregulation in the adjacent and non-adjacent gene pair sets.
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In "The TF-miRNA Coregulation Network in Oral Lichen Planus," Y.-L.
For each pair, we contrasted the coregulation observed in E. coli with a null averaged value obtained with randomized networks (Materials and methods and text S1 section 2).
This thus helped explain why we found a small, but significant, FFLness in the large regulon-size class: this signal is a mixture of the non-significant and significant coregulations represented in the decayed, but yet significant, total score (Fig. 2.D).
In order to assess the role of RBP1, if any, in coregulation of Runx2 activity, transient transfection analyses were conducted using two known Runx2-responsive luciferase reporter constructs, p6OSE2-Luc [ 14] and the mouse osteocalcin promoter [ 14].
ZNF367 and KRCP are putative transcription factors that act as central nodes in gene coregulation networks, and their function in the nervous system is unknown.
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