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Moreover, since the difference persisted in the B. abortus and B. melitensis manBcore mutants (which display similar core stubs), it is unlikely that core variations in B. abortus and B. melitensis could account for it.
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SAR was obtained by modification of the benzazepinone core, variation of the spacer linking guanidine moiety and core, and modification of the guanidine mimetic.
Compared with the previous designs of porous fiber core, variation of the signal amplitude with exterior refractive index is demonstrated to be contrary to that of the sensitivity in the proposed fiber, contributing to optimized detecting accuracy over a large refractive index range of 1.33 to 1.42.
As such core variation is clearly a general phenomenon in bacteria, it would be useful to determine its mechanism.
Such preliminary filtering step removing those poorly represented families greatly facilitated the detection of the core variation and interactions among families.
In an attempt to explore whether core variation might have an impact on response irrespective of rs12979860, the viral kinetics in patients carrying the CT SNP genotype and different HCV core variants was compared.
However, we did not find any significant association between rs12979860 and core aa 70 and an impact of core variation at residue 70 on response was observed also within the group that carried CT at rs12979860: the decline in HCV RNA was steeper in patients infected with HCV with R70 as compared with Q70.
It is remarkable that a very similar pattern of replacement of fGIs has been found in 113 genomes of V. cholera (Mutreja et al. 2011) in which also within a background of very little core variation there was a replacement of the O-chain polysaccharide gene cluster and the giant protein gene described before.
This observation may be relevant for investigations of how core variation influences treatment response in different populations of patients with hepatitis C, firstly because the distribution of IL28B SNP genotypes differ between ethnic groups [ 15, 17] and secondly because SNP differences may bias the results.
The results of our study may provide an analog for down-core variations of magnetic parameters associated with modification of magnetic minerals during reductive diagenesis.
The variations of magnetic properties of the bottom sediments with water depth in Lake Ogawara (Fig. 4) represent a profile analogous to such down-core variations.
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