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SAR was obtained by modification of the benzazepinone core, variation of the spacer linking guanidine moiety and core, and modification of the guanidine mimetic.
Compared with the previous designs of porous fiber core, variation of the signal amplitude with exterior refractive index is demonstrated to be contrary to that of the sensitivity in the proposed fiber, contributing to optimized detecting accuracy over a large refractive index range of 1.33 to 1.42.
As such core variation is clearly a general phenomenon in bacteria, it would be useful to determine its mechanism.
Such preliminary filtering step removing those poorly represented families greatly facilitated the detection of the core variation and interactions among families.
In an attempt to explore whether core variation might have an impact on response irrespective of rs12979860, the viral kinetics in patients carrying the CT SNP genotype and different HCV core variants was compared.
However, we did not find any significant association between rs12979860 and core aa 70 and an impact of core variation at residue 70 on response was observed also within the group that carried CT at rs12979860: the decline in HCV RNA was steeper in patients infected with HCV with R70 as compared with Q70.
Similar(51)
Moreover, since the difference persisted in the B. abortus and B. melitensis manBcore mutants (which display similar core stubs), it is unlikely that core variations in B. abortus and B. melitensis could account for it.
Seventeen cases (22%) had discordant scores following TMA analysis, due either to inter-observer variation or inter-core variation, and were subject to further testing and independent scoring using whole FFPE sections.
The variations of magnetic properties of the bottom sediments with water depth in Lake Ogawara (Fig. 4) represent a profile analogous to such down-core variations.
The results of our study may provide an analog for down-core variations of magnetic parameters associated with modification of magnetic minerals during reductive diagenesis.
We propose that the magnetic properties of surficial sediments are controlled by limnological stratification of the brackish lake water, thus possibly providing an analog for down-core variations of magnetic parameters associated with the modification of magnetic minerals during reductive diagenesis.
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