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The Picker adult inpatient questionnaire, comprising 40 items, has been reduced to a core set of items that have been validated for use across different settings, termed the Picker Patient Experience 15, or PPE-15 [ 21].
The comparison of the MeSH-profiles yielded (i) index terms specific for each corpus (Schuemie: 26 terms, MeSH-MI: 22 terms, MeSH-Med: 29 terms), (ii) pairwise intersections, and (iii) a core set of 11 terms found in all three profiles.
This core set of items showed good item fit.
At the functional level, a core set of 558 Kegg terms (>50%) were common to all tissues, accounting for 94% of annotated reads.
Figure 1 shows the sensitivity analysis for setting a threshold percentage for inclusion of a term in the core set of surgical conditions.
For GO terms in evaluation categories with association counts in the ranges [11, 30], [31, 100], and [101, 300], we compute gene/term scores one term at a time, starting by identifying the "core set" of genes that have positive associations with the current GO term.
Expression of these genes is conserved across Eutheria and likely represents a core set of transcripts important for placenta function, especially at term.
Since, tRNA related terms are only found in the core set of DEG shared by all genotypes, we conclude that these most likely are not related to the resistance conferred by Qfhs.ifa-5A.
Crucially, the loss of genomic synteny (i.e., collinearity) in evolutionary time, even when a core set of shared genes is maintained, suggests that a virus should be defined in terms of a core set of genes essential for survival that exist in a constant state of flux upon a changing background of conserved, host gene-regulatory-networks.
Transcription factors are known preferential, direct targets for miRNAs [18], and among the core set of up-regulated transcripts, only the "transcription factor activity" GO molecular function term was highly over-represented (Table 1).
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