Sentence examples for core set of pathways from inspiring English sources
Since all cellular life possesses the core set of pathways we're interested in reconstructing, a comparison of the metabolic paths of extant organisms would only reflect differences in metabolic regulation rather than differences in structure.
We identified a core set of pathways, homogeneously enriched throughout nearly all diseases.
Although we found a core set of pathways across diseases, differences between disorders can arise due to different expression levels of the respective microRNAs.
However, the core set of pathways under strong microRNA control appear to be homogeneously enriched throughout the majority of diseases, since many diseases are linked to a large number of microRNAs.
Conversely, a signature with high predictive value suggests that the phospho-sites included in the signature are part of a core set of pathways that are universally operative in the disease.
However, it would appear that a core set of pathways (TP53, RB1/cell cycle, and PI3K/AKT/mTOR) is compromised in both HPV+ and HPV- oropharyngeal tumors, thus targeted therapies directed against one or more of these pathways could be efficacious in both contexts.
The authors examined the abundances of microbial metabolic pathways including the relative abundances of individual enzyme families Kyoto encyclopaedia of genes and genomes (KEGG), Orthologous groups and of complete metabolic modules, identifying a core set of metabolic pathways present across these diverse digestive tract habitats.
We define this cluster as the core set of signaling pathways highly enriched with disease-associated microRNA targets.
On a global scale, we found a core set of signaling pathways with enriched tissue-specific microRNA targets across diseases.
This indicates that disease-associated microRNAs in human disorders target a core set of signaling pathways irrespective of the specific disease and tissue.
We define for each tool the core set of signaling pathways, which are highly enriched by microRNA targets and compare these list with our core set listed in Table 1.
