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This demonstrates that a core response to TCDD is conserved across species.
Transcriptional profiling revealed a large core response to different sources of plant biomass in N. crassa.
The functional enrichment in downregulated genes was remarkably reminiscent of the core response to environmental stress in yeast: repression of genes related to protein synthesis aimed at conserving energy (Gasch et al., 2000).
To examine more closely the correlations between the genes of the core response to MAB infection, we incorporated a network based approach using experimentally-validated interactions from the InnateDB database [ 22].
In C. glabrata the core response to oxidative stress included thioredoxin peroxidases (CgTsa1, CgTsa2), thioredoxin reductases (CgTrr1, CgTrr2), the thioredoxin cofactor CgTrx2, the glutathione peroxidase CgGpx2, and the catalase CgCta1.
Seventy three of the core response genes to MAB were also identified as part of the core response to MTB (Additional file 6: Table S3), representing a highly significant overlap (P < 5.482e-24, hypergeometest test) and suggesting a conserved role for type-I IFN responses across diverse mycobacterial species.
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Overlap of the core responses to MAB and MTB.
Our results showed a high degree of cross-species module similarity between PMM and PMT under iron depletion condition, and between SYW and SYG under high copper condition, suggesting possible core responses to each treatment.
This shows that major responses to drought stress are family specific and not part of the core responses to drought stress.> -wrap-foot> A global unbiased metabolic profiling platform from both plant species was used as previously described (Evans et al. 2009 [ 16]).
A compendium of human responses to many different pathogens described in [24] was used to provide dynamics of the core response module to Salmonella infection.
In order to elucidate regulatory influences of the core response module to provide a comprehensive, parsimonious regulatory network we apply a multivariate regression technique.
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