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Finally, we extend our gratitude to members in core research facilities for laboratory animals and mass spectrometry for technical assistance.

We are grateful for the services of the University of Utah Health Science Center core research facility for DNA sequencing and synthesis of oligonucleotides (partially funded by NCI CA04214).

An alternative approach is for the domestic researcher--you--to include foreign research expenses--yes, NIH will pay even core research costs for your foreign colleague--as a subcontract.

The core research question for this steam is 'How is the ED time target policy implemented?' This stream involves qualitative research into the four case study hospitals.

The core research question for this stream is 'What impact do different initiatives aimed at the ED performance target have on measures of patient flow?

The core research questions for this stream are; 'Was there a change in clinically relevant outcomes after the target was introduced?' and 'Were there differential impacts of the target in at risk ethnic, age and deprivation groups?' We will investigate whether the rate of change of quality of care markers differs over time, pre and post introduction of the ED time targets in July 2009.

There is already considerable opposition to the proposed UK Research and Innovation, the politicised conglomerate that will swallow up the independent research councils and become responsible for core research funding in English universities.

In addition to doubling the NSF and DOE science budgets over 10 years, the administration has promised to do the same for core research programs at the National Institute of Standards and Technology NISTT).

Because it is not intended to pay for core research activities, it is limited to $32,000 a year in direct costs.

This lack of support for core research infrastructure was reflected in concerns about ability to cover the total costs of clinical research in an increasingly resource-constrained practice environment.

However, it is also clear that nested trials are likely to require additional resources for both the core research team running the nested studies and the host studies on which they are run.

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