For specimens histologically non-homogeneous we extracted more tissue cores, representative of the different areas.
"It must be from a neutral group and comprise non-core representatives of all colours, and all colour leaders must be excluded," he said.
The refinement step builds a set of core representatives by comparing the authority profiles of all members (except members from proteomes with multiple representatives) with the chief authority.
The pre-treatment core biopsy may not be available if it was performed in another centre, and it must be assumed cellularity in the core is representative of tumour cellularity as a whole.
A single observation was used if only one tissue core was representative of cancer cells.
Each L-SCC core was representative of the invasive tumour as assessed by H&E analysis from single sections.
All medical schools involved offered a standard core curriculum representative of that given by other medical schools in Italy, in which drug addiction is a topic of the fourth year.
Although it is a reasonable contention, given the well-known intrinsic heterogeneity of breast cancer, this limitation was overcome by using two 3-mm tissue cores because it was previously reported that TMA with two 0.6-mm cores were representative of standard full tissue sections in breast cancer [ 21].
Those provisions are investigated by considering a postulated core degraded state representative of the end of the transition phase.
The question that begs for an answer is how to identify the core that is representative of a network's dynamics, its function and robustness.
Yet despite the limited number of cores obtained, skeletal growth trends within each reef zone were relatively consistent amongst cores (Fig. 4 ., which suggests that the analyzed cores are indeed representative of the greater population of S. siderea inhabiting the respective reef zones.
