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Switching to a higher fluorinated central core reinstated high MEK potency, leading to two new preclinical candidates with long half-lives, high bioavailabilities, low brain penetration potential and convincing efficacy in a K-Ras-mutated A549 xenograft model.
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In 1976 the court reinstated it.
JJ Abrams's cinematic reboot of Star Trek, out on Friday, is already earning praise for returning the tired space franchise to its core values and reinstating the characters that made it great in the first place.
Limiting expansion of the ischemic core lesion by reinstating blood flow and protecting the penumbral cells is a priority in acute stroke treatment.
When the current artistic director, Carey Perloff, took over in 1992, she reinstated a small core acting company, expanded the educational offerings and earned praise, in particular, for her productions of Tom Stoppard plays.
And colleges are loath to reinstate the core curriculums they abandoned in the '60s.
We must have the confidence to reinstate the core values that made us want to become social workers.
The forced core thermoregulation was held periodically to assess the relapse of hyperthermia and was reinstated as required.
He partially reinstated them.
National symbols were reinstated.
(It was later reinstated).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com