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To gain insights into Dichaete function in the ventral nerve cord we focused our attentions on some of the core regulatory pathways controlling neural differentiation.
In this study, seven proteasome targets were also identified (though not PSMD14) supporting that, while the specific regulatory proteins identified may differ across cancer types, the core regulatory pathways may be conserved in Mcl1-dependent cancers.
Transcriptomic data of a subset of genes predicted to be involved in asexual development in Aspergillus are shown in Table 4. Expression profiles of orthologous genes belonging to the two core regulatory pathways identified in A. nidulans, STUNTED (stuA→ wetA) and BRISTLE (brlA→ abaA→ wetA) [ 40, 41] suggest conservation of these regulatory pathways between the two Aspergilli.
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It is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of cross-links in collagens and elastin, a key component in the core regulatory pathway of fibrogenesis.
(A ) Core apoptotic regulatory pathway with C. elegans gene names indicated (mammalian counterparts in parentheses).
DOI: http://dx.doi.org/10.7554/eLife.04265.008 10.7554/eLiFigure65.009 Figure 2 figure supplement 3. The core apoptotic regulatory pathway acts in parallel to miRISC for normal development.
These modules are likely involved in core synaptic and regulatory pathways that are affected in both ID and ASD.
Although much progress has been made for understanding the core regulatory machine of Egr-Bsk pathway, other signaling pathways that modulate Bsk-mediated cell death have not been fully elucidated.
Complex phenotypic changes typically arise from re-regulated cellular signaling and regulatory pathways (core pathways).
To reveal the internal mechanism of the Xenopus embryonic cell cycle, we assume that all of the cells are coupled indirectly through the common extracellular medium, in other words, they are coupled through a complex protein (R) that excites the protein of Cyclin-CDK1 in the core cell cycle regulatory pathway.
The level of transcription for any given gene depends on the integration of its different regulatory pathways at the core promoter.
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