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These protein complexes, evolutionarily conserved from bacteria to humans, are core regulators of cellular metabolism.
In this study, we characterized the core regulators of c-di-GMP turnover in B. amyloliquefaciens PG12.
Core regulators of epithelial basolateral membrane identity localize to T-tubules, and knockdown of AP-1γ, required for basolateral trafficking, redirects FGF from T-tubules to surface, increasing tracheal surface ramification and preventing invasion.
Neither BRD9 inhibition nor ARID1A deletion resulted in significant changes in the core regulators of pluripotency, Pou5f1 or Sox2, consistent with what has been observed previously in BRG1-deficient ESCs11,12.
This supports a scenario in which CYCD3s are core regulators of cambial cell proliferation in both shoots and roots.
The second regulator in the list is one of the core regulators of the cell cycle, E2F2 (Trimarchi and Lees, 2002).
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The myosin phosphatase is also a well known core regulator of the actomyosin pathway, inhibiting the myosin activity [18].
Those results clearly show that miR-200a is a core regulator of module 25, most probably with other members of the miR-200 family.
It has also been shown that hES cells and mouse spermatogonial cells express the core regulator of promiscuous expression of tissue specific genes in medullary thymic epithelial cells, the Aire gene [8], [15].
Notably, S6K is the core regulator of glycolysis [ 17].
The nutrient sensor mTOR (mammalian target of rapamycin) is likely the core regulator of autophagy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com