Exact(1)
This hypothetical feedback action is consistent with the model proposed by Tòth and colleagues [53], in which the photoreceptors send the "light-on" signal to the clock core, and the core regulates their expression, forming a regulatory loop.
Similar(59)
Our biochemical and structural studies reveal how different motifs and domains flanking the catalytic core regulate substrate selectivity without significantly affecting the intrinsic kinase activity, whereas a rubredoxin-like domain is shown to downregulate catalysis through specific intramolecular interactions that modulate access to a profound substrate-binding site.
Briefly, genes passing the filter in one or both conditions made up the core regulated dataset.
Core differentially regulated miRNAs by both treatments suggest roles in regulating lipogenic pathways or mammary gland functions.
Of these 31 core growth regulated genes 26 have homologs in P. pastoris, and of these 21 (81%) were regulated in the same manner (Supporting information, Tables S1 and S2).
Our study provides an invaluable resource for further mechanistic studies and suggests core factors regulating pre-implantation embryo development.
Conformational changes observed in these domains on DNA binding suggest that they transduce DNA-induced conformational changes to the catalytic core and regulate kinase activity.
Despite extensive efforts, mechanisms for how three core components regulate MLL/SET1 methyltransferase activity remain elusive.
A third subunit (B, B', B" or B" ') can eventually bind to the core and regulate both the substrate specificity and localization of the trimeric holoenzyme.
Functional classification of genes showed over-representation of genes involved in core processes regulating nucleic acids (nucleic acid metabolism/nucleic acid binding/transcription category) in the severely attenuated mutants, thus implying their significance in intraerythrocytic development and potential as high value targets for therapeutic intervention.
It appears that the access of lipases to the LD core is regulated, at least in part, by PAT proteins.
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