Sentence examples for core regulate from inspiring English sources

Our biochemical and structural studies reveal how different motifs and domains flanking the catalytic core regulate substrate selectivity without significantly affecting the intrinsic kinase activity, whereas a rubredoxin-like domain is shown to downregulate catalysis through specific intramolecular interactions that modulate access to a profound substrate-binding site.

This hypothetical feedback action is consistent with the model proposed by Tòth and colleagues [53], in which the photoreceptors send the "light-on" signal to the clock core, and the core regulates their expression, forming a regulatory loop.

Briefly, genes passing the filter in one or both conditions made up the core regulated dataset.

Conformational changes observed in these domains on DNA binding suggest that they transduce DNA-induced conformational changes to the catalytic core and regulate kinase activity.

Despite extensive efforts, mechanisms for how three core components regulate MLL/SET1 methyltransferase activity remain elusive.

A third subunit (B, B', B" or B" ') can eventually bind to the core and regulate both the substrate specificity and localization of the trimeric holoenzyme.

We were also curious to see if MYC and core TFs regulate the same transcriptional circuitry or operate individually.

The small GTPase Rac1 would activate the JNKKK Slpr, which in turn would activate JNK signaling core to regulate dilp8 expression and ultimately favor development delay and tissue homeostasis maintenance.

These results are consistent with the effect of HCV core protein on RANTES mRNA levels and suggest that the core protein regulates RANTES expression by influencing its promoter activity.

Our study provides an invaluable resource for further mechanistic studies and suggests core factors regulating pre-implantation embryo development.

Functional classification of genes showed over-representation of genes involved in core processes regulating nucleic acids (nucleic acid metabolism/nucleic acid binding/transcription category) in the severely attenuated mutants, thus implying their significance in intraerythrocytic development and potential as high value targets for therapeutic intervention.