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The core reactions conforms a single cluster of permanently connected metabolic processes where the activity is highly synchronized representing the main integrators of metabolic activity.
The number of core reactions in the model are 45.
The inclusion of non-penalized reactions is, unlike core reactions, not forced, but only preferred over the inclusion of penalized non-core reactions.
Reactions with a high level of confidence are supported by at least two core reactions.
Core reactions were then subjected to subsequent modularization and BN analysis.
BioPAX Interaction elements are translated into SBML core reactions and qual transitions.
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The remaining non-core reactions have a low confidence score as they themselves are not supported by Barcode and their inclusion in the model depends on a single core reaction only.
Other reactions, the rate coefficient of which can be zero in certain realizations, are called non-core reactions.
The former requirement is waived when removing non-core reactions whose associated genes are not expressed in any tissue samples.
Alternate gap-filling solutions can be computed by changing weightings on non-core reactions in the preprocessed problem.
For non-core reactions, we use network topology to define a secondary metric called connectivity-based evidence E c (r).
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