Rather, it implies that variance related to PD needs that is explained by these variables is already subsumed by the four core predictors in the model.
We have identified three core predictors of good governance: 1) the jurisdiction/authority of governance groups; 2) the skills and knowledge of governance groups, as well as their resources and motivation to make and enforce rules; and 3) the power of governance groups to exert legitimate authority and not be undermined by other less legitimate but more politically or economically powerful actors.
For example, Research has reported that the presence of chronic diseases is one of core predictors of SRH [ 25, 26].
Strikingly, the core predictors are able to predict expression as well as POL2, particularly at low to moderate expression levels.
Overall, predictors identified in the multivariate model in SSc-APAH were very similar to the core predictors for PAH as a whole, including all subtypes.
For the sake of completeness, we also predicted gene expression using our core predictors inside whole gene boundaries instead of just around TSSs.
Surprisingly, even when the core predictors are used together, the combined predictive power does not improve much compared to using chromatin accessibility alone.
In all, enabling factors rather than need factors were the core predictors of frequency of service utilisation by patients with SMD.
This study reveals that health care system organisation and professional practice - rather than patient need profiles - are the core predictors of professional consultation by patients with SMD.
Only the general factors Pol2, TAF1, and TBP, and the histone marks H3K27ac, H3K4me3, and H3K9ac stand out as adding substantial information beyond our core predictors.
Finally, the plots of Fig. 5f show the comparative trends of the gene expression predicted using the TSS ChIP-seq signals of POL2 (which is directly involved in transcription) and the TSS signal levels of the core predictors.
