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Table 1 summarizes core phenotypic features of 30 NCS patients (27 confirmed and three inferred WDR73 c.888delT homozygotes) ages 1.4 to 28 years (mean age 9.2 years).
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We suggest that the lowered level of these core pluripotency regulators is sufficient to maintain several phenotypic features in OSKMV cells consistent with conventially derived OSKM iPSCs.
In contrast, Adamo et al. (2010) observe that deletion of lig-4 in Caenorhabditis elegans fcd-2 mutant strains restores meiotic and ICL repair defects and that the knockdown or drug inhibition of DNA-PKcs suppresses phenotypic features of transformed human cells lacking FA core complex or FANCD2 proteins.
In general, annotation of less specific phenotypic features might decrease the observed overall similarity between phenotypes.
This model recapitulates many phenotypic features of WS.
a Phenotypic features of GNS4 RNAi and overexpression transgenic plants.
They have similarity in many phenotypic features except motility.
A major challenge in biology is to understand how molecular processes determine phenotypic features.
We profile 554 essential C. elegans genes by imaging gonad architecture and scoring 94 phenotypic features.
To determine whether European Americans with polycystic ovary syndrome (PCOS) exhibit genetic differences associated with PCOS status and phenotypic features.
We analyzed the functional roles of these orthologous genes in determining the phenotypic features of S. pastorianus.
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