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Because the core phase of our study has been scheduled for a maximum of 3 years at study initiation, an extension phase is now planned in order to collect follow-up clinical data of the study cohort (progression index, time to conversion to clinically definite and chronic-progressive MS).
Furthermore, the rates of discontinuation during the 1-year core phase of the study were similar for patients randomized to DFO or deferasirox (Vichinsky et al, 2007).
Therefore, after completing the 1-year core phase of the ESCALATOR trial, cardiac iron was evaluated in Omani trial patients as part of standard-of-care practice.
During the 1-year core phase of study 4, all patients started on deferasirox 20 mg/kg per d except three who started on 10 mg/kg per d (Taher et al, 2009).
During the core phase of the study, the frequency of sickle cell crisis was comparable in patients randomized to deferasirox (33·3%) and DFO (31·7%), suggesting that incidence is comparable irrespective of chelator type (Vichinsky et al, 2007).
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The objective of this study is to evaluate the environmental impact of the Italian gray cement and clinker industry, after distinguishing between the upstream and the core phases of these processes.
Injury control research centers study the three core phases of injury control prevention, acute care and rehabilitation and serve as training and information centers for the public and health professionals.
Studies into VE for safety learning and training should address the need of this process, and in particular the three core phases of: risk identification, risk evaluation, and risk response planning.
"The one time you really don't want to get pregnant is when you're single and the other person is married and you're working as a first-year junior associate at a law firm in a hard-core phase of trying to prove yourself to them," Ms. Greenfield recalled last week.
Overall, 298 patients aged 18 60 years with ADHD who had either completed the core study or discontinued from the maintenance of effect phase of the core study (due to lack of therapeutic effect) entered the extension study.
Treatment non-responders were defined as patients who fulfilled both the lack of therapeutic effect criteria in the maintenance of effect phase of the core study.
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