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However, some systems have been held to be indispensable, for example, the core pathways of carbon metabolism that produce energy from sugars.
We predict that, as future studies increase the number of SCZD-patient-derived neurons, core pathways of genes that contribute to this disorder will be identified.
As expected, core pathways of metabolism, such as glycolysis and the pentose phosphate pathway, are also among the most commonly represented in the set of EC numbers common to all three organisms.
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Indeed, we have experimentally validated that Notch signaling is the core pathway of hypoxia tolerance in D. melanogaster.
The interaction between CDK4 and CDKN2A is part of the third and final core pathway of GBM, as defined by the TCGA consortium.
To date, nearly all genes responsible for biosynthetic steps have been identified, leading to the clarification of the core pathway of GS biosynthesis in Brassicaceae (Supplementary Fig. S1).
Thus, albeit a core pathway of RdDM in A. thaliana as a model plant is known, genetic analysis in a transgene-based experimental system shortcutting part of the pathway has provided important information.
Importantly, inactivation of autophagy in kidney and lung fibrogenic cells also reduced their capacity to drive a fibrogenic response [ 32], identifying autophagy as a potential core pathway of fibrogenesis.
Molecular network can be divided into regions representative of different cellular mechanisms: a) the TGF-β pathways that appears as the core pathway of the general atrophy network, b) the NFKB pathway and its correlated responses, c) the negative regulation of cell cycle, d) the response to apoptosis and inflammation.
One of the core pathways downstream of FGF is the mitogen-activated protein kinase (MAPK) pathway [ 11], which has a central role in transmitting cell proliferation and survival signals [ 12].
S metabolism is a core pathway for the synthesis of molecules required for some environmental stresses including Al [ 4, 10].
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