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However, the success of this strategy was limited presumably because these core pathways have numerous compensatory mechanisms, including the network of endocrine factors providing homeostatic compensation.
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Analysis of KEGG pathway expression showed that 32 of the 40 core pathways had significant differences in transcript representation.
In the past decade, tremendous progress has been made in our understanding of the molecular genetics of tocochromanol synthesis in plants and cyanobacteria, and all the biosynthetic genes of the core pathway have now been cloned and studied in detail.
In the pupal wing, the core pathway has already been linked to regulation of E-cad trafficking, and evidence has been presented that this promotes junctional remodelling that gives rise to a regular hexagonal arrangement of the cells (Classen et al., 2005).
However, further investigation to understand the cumulative influence that gene interactions have and the multi-faceted role that PPAR and other core biological pathways have on phenotypic expression of growth and carcass traits is warranted.
Multiple negative feedbacks regulating the core components of small RNA silencing pathways have been reported [ 1, 31, 32, 36, 40].
At least four distinct small RNA-generating pathways have been identified in Arabidopsis; each associated with a subset of the core silencing factors [2], [3].
Despite shared core pathways, Cdx paralogues have acquired distinct regulatory roles during development.
Furthermore, proteins that were core proteins in certain pathways (e.g., Cdc28 in both cell cycle pathways) had very low bow tie scores in other pathways.
Scenarios 1) and 2) can only be investigated when all core genes of the STX pathway have been fully characterized in STX-producing species.
Traditionally, two pathways had been imagined.
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