Sentence examples for core pathway in from inspiring English sources

In summary, both RLS and CLS extensions confirm the beneficial role of the CORE pathway in the context of cellular aging.

These 13 polypeptides are all components of the respiratory chain, the core pathway in oxidative phosphorylation, the activity of which is the primary function of mitochondria.

We therefore considered this to be a good context in which to investigate the role of the core pathway in cell intercalation.

The only core pathway in these two stages is the ubiquitin-mediated proteolysis pathway, which is a significant cue of carcinogenesis from early to late stage bladder cancer.

Transforming growth factor-β is the pre-eminent signal for connective tissue synthesis, and is considered as a "core pathway" in both normal wound healing and pathological fibrosis.

As Rac is not an effector of the core pathway in other contexts in Drosophila (Hakeda-Suzuki et al., 2002), we focused our attention on the single Rho homologue RhoA (Rho1 – FlyBase).

"Bottom-up" in vitro SCRaMbLE starts with a centromeric acceptor vector and a series of "donor fragments"; the basic goal here is to evaluate a series of candidate genes (represented as "donor fragments") for their ability to boost production of the core pathway (resident in the chromosome in a non-SCRaMbLEable format) (Fig. 3a).

Furthermore, pSrc remains asymmetric in the absence of core pathway activity in the epidermis (supplementary material Fig. S3G) and is also unaltered in the tracheal system (Förster and Luschnig, 2012; Nelson et al., 2012).

More specifically, as NMDAR hypofunction is a core pathway deficit in schizophrenia [ 19, 20], DAAO inhibitors, perhaps in combination with D-serine systemic administration [ 21], have the potential to be effective treatments of schizophrenia via their capacity to increase D-serine in the brain and enhance NMDAR-dependent functions [ 13, 14, 22].

We sought to examine the roles of the four core pathway genes in eye development by generating eyes that were completely homozygous mutant.

However, arguing against Src acting together with the core pathway, Src in part modulates E-cad by altering its transcription (Shindo et al., 2008), whereas in core pathway mutants we see no change in expression of a reporter of E-cad transcription (Fig. 4M).