Sentence examples for core pathogenesis of from inspiring English sources
By analogy, we hypothesized that the blockade of HERG1 channels by antipsychotics, which is responsible for the acquired LQT side effects, might also be involved in the therapeutic mechanism of these drugs, thereby providing a clue to the core pathogenesis of SCH.
CPH is exceptional with clinical similarities; the absolute indomethacin effect suggests a shared, core pathogenesis.
Structural alterations of the cellular prion protein (PrPC) seem to be the core of the pathogenesis of prion diseases.
Indeed, the breakdown of B cell tolerance for autoantigens may be at the core of the pathogenesis of SLE and RA and perhaps of other autoimmune diseases.
This finding parallels that in which the number of cores in central core disease likewise shows no correlation with the disease [ 45] although the cores are linked to the pathogenesis of the central core disease.
IFN-γ has long been considered the core cytokine in the pathogenesis of SLE [ 47].
Insulin resistance is a core defect in the pathogenesis of type 2 diabetes, and the condition is associated with increased risk for diabetes already in early adulthood (1– 4).
In recent years, the study found that microglia cells (MG) play a core role in the pathogenesis of AD, which is currently one of the hot topics in the study of the nervous system degenerative disease.
The core event in the pathogenesis of CIS is the developmental arrest of primordial germ cells (PGCs) or gonocytes, which remain locked in an immature state as 'dormant' or pre-CIS cells during fetal and postnatal life.
Whilst this is the only established direct regulatory pathway linking the core clock and the pathogenesis of RA, several clock outputs (including hormones and clock-controlled genes) have been attributed roles, and these are expanded on below.
To further characterize the core regulatory genes involved in the pathogenesis of ICP, genes associated with the significantly enriched GO terms were used to construct gene-interaction and gene co-expression networks [ 21, 26].
