Sentence examples for core pacemaker from inspiring English sources

Although the core pacemaker involves about a dozen genes, the number of genes that exhibit oscillatory behavior (the circadian output genes) may be much greater.

Taken together, our results identify USP2 as a new core component of the clock machinery and demonstrate a role for deubiquitination in the regulation of the circadian clock, both at the level of the core pacemaker and its response to external cues.

Though PDF signaling does not contribute to the molecular effect of shits1, period lengthening may occur through perturbation of other intercellular signals specific to core pacemakers.

PDF is the only known neurotransmitter output of the core LNv pacemaker cells and is thought to mediate synchrony among the sLNv and between pacemaker groups [16], [21].

Patients that used heart pacemakers were excluded.

Its once spectacular revenue growth has slowed to a crawl on stagnant sales for its core cardiac defibrillator and pacemaker products, mounting skepticism over its back-surgery devices and industrywide price pressures.

At its core, the molecular circadian pacemaker is driven by the CLOCK/BMAL transcriptional activator complex.

Thus, not only does shits1 alter behavioral period but also alters in a parallel manner the rhythms of the core molecular oscillator in the master pacemaker sLNv.

It may be opportune at this crossroads in chronobiological research to consider alternatives for the eukaryotic pacemaker such as a core PTO embedded in a TTFL akin to that found in cyanobacteria.

In individuals with a long intrinsic period of the central circadian pacemaker, the nadir of the core body temperature rhythm, the onset of nocturnal melatonin, and the preferred timing of sleep are all located at a later clock time than in individuals with a shorter circadian period (22, 23).

To characterize the amplitude dynamics of the circadian pacemaker we propose a stochastic dynamic model of core temperature data that contains both stochastic and dynamic characteristics.