Resveratrol, in contrast, activates the Sirt1 catalytic core independent of the terminal domains, indicating a binding site within the catalytic core and suggesting that small molecule activators for other isoforms might also exist.
You can improvise a male connector by wrapping a screw (which will be the center terminal) with insulating tape and then cutting a "T" shaped piece of sheet metal and bending it to fit between the cartridge's outer terminal and around the taped core of the center terminal.
Conversely, Trp residues are not particularly conserved in the LRRCE sequences, and the only Trp residue in the structure of bovine decorin [ 29] is exposed to the solvent and does not participate in the hydrophobic core of the C-terminal end of the LRR structure.
Aiming to rationalize the parameters governing such interactions eight types of these polycationic dendrimers in which the generation, the number of charges, the nature of the core and of the terminal groups vary from one to another, were designed and used.
In D. melanogaster, hkb is a core component of the terminal patterning system, a development pathway involved in setting up the anterior and posterior ends of the embryo in hexapod arthropods [ 103, 104].
Like the N-terminal domain, the inner core of the C-terminal CupB2 Ig domain is also packed with hydrophobic/aromatic residues such as Leu, Ile Phe, Tyr and Trp.
Sequence comparison studies and functional analyses indicate that the combination of C-terminal activator motifs (AHA motifs) adjacent to a nuclear export signal (NES) represents the core of the C-terminal activation domain (CTAD) for many plant class A Hsfs [ 13, 18].
Likewise, the topology and core of the C-terminal domain are conserved.
Trp43 is located in the highly conserved region of γD-crystallin, and is also located in the hydrophobic core of the N-terminal domain (Basak, et al.., 2003).
The five-helix bundle that comprises the core of the C-terminal actin-binding domain of talin contains a number of conserved surface-exposed residues that are predominantly clustered on the face made up of helices 3 and 4.
