Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations.
Since all cellular life possesses the core set of pathways we're interested in reconstructing, a comparison of the metabolic paths of extant organisms would only reflect differences in metabolic regulation rather than differences in structure.
We identified a core set of pathways, homogeneously enriched throughout nearly all diseases.
Although we found a core set of pathways across diseases, differences between disorders can arise due to different expression levels of the respective microRNAs.
Conversely, a signature with high predictive value suggests that the phospho-sites included in the signature are part of a core set of pathways that are universally operative in the disease.
However, the core set of pathways under strong microRNA control appear to be homogeneously enriched throughout the majority of diseases, since many diseases are linked to a large number of microRNAs.
Thus, it is possible to uncover the core reactions of pathways, and the additional inventions during evolution, in a manner consistent with current biological knowledge.
The absence of such a core is an intuitive explanation for the absence of a metabolic core of degradation pathways: different metabolic environments imply different metabolic pathways.
In this work we present a constraint-based analysis of a metabolic network integrated by a core of metabolic pathways participating in cancer cell growth: glycolysis, TCA cycle, pentose phosphate pathways (PPP) and oxidative phosphorylation.
Based on these comparisons, we detected a core of metabolic pathways associated with central carbohydrate metabolism, lipid, cell wall, and cofactors, and biosynthetic pathways.
In a recent review [ 16] Bourgeron compared all available information on the genetics of early-onset neurodevelopmental disorders in order to identify a common core of altered pathways affecting neuronal homeostasis.
