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Therefore, the design of biologically sound as well as computationally tractable models for inferring modules has been at the core of functional genomics throughout the post-genomic era.
Insertional mutagenesis has been at the core of functional genomics in many species.
Given these complementary techniques, a combination of both approaches should yield robust evidence for the "core" of functional connectivity in neural networks.
Based on that and on the fact that we analysed reactions instead of genes (partially addressing the issue of NOGD), we therefore expected to find a small core of functional capabilities.
The notion of a conserved core of functional genes in the microbiome has been supported by studies in monozygote and dizygote twin pairs, though major differences in the abundance of microbes at the phylum level were observed in the microbiome of obese compared with lean twins (Turnbaugh and Gordon 2009; Turnbaugh et al. 2009a).
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The cores of functional sphere thus are overlapping (Figure 5). Figure 5 Triple helix internal core-external field model in functional sphere perspective.
Thus, the conservation of the total proportion of hydrophobic amino acids in P. falciparum, and the compensative behavior of other amino acid couples, gives evidence for the conservation of hydrophobic cores of functional domains.
However, it is important to note that although the participants improved function during the rehabilitation period, they still report significantly lower function on all core aspects of functional health status compared to a normative sample from the Ullensaker study (N = 2864) [ 38] at all points of measurement.
However, a comparison of present musculoskeletal pain sample with a normative randomized sample (N = 2864) from the Ullensaker study [ 38] on the COOP/WONCA charts, demonstrates that the musculoskeletal pain sample (N = 143) still report significantly lower function (p < 0.01) on all core aspects of functional health status at the end of the 57-week rehabilitation period.
This may help to understand the basis of gene regulation, the core task of functional genomics.
During the ping-pong games Brandon, Ilana, and I tried to come up with a metaphor that would explain the core concepts of Functional Programming to non-programmers: 6-year-olds and Art majors.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com