The initial hit, MW069a, was obtained by alternative placement of the pyridine substituent on the pyridazine core of a safe, brain penetrant experimental therapeutic, MW189.
However, those nodes below the synthetic network were concentrated in the region of the posterior cingulate and precuneus, a location known to be a core of the brain network [39].
Using the cannula only of a biopsy needle (Seldinger needle, 18 g, 7 cms, Scottish Medical) a "core" of selected brain area was sampled by punching through the brain slice.
In an ischemic attack, a core of brain cells at the center of the affected region dies quickly.
Like my phobia, this feeling was internal, psychosomatic, but felt incredibly real, tapping into a different but equally ancient core of my brain.
The title, "*Corpus Callosum," refers to the core of the brain, which was once thought to be where a human's soul resided.
He singled out her hypothalamus, an almond-sized hormonal regulator in the core of the brain, because the PET showed that it was overactive.
This has enabled us to map from the cellular level, from the basic core of what brain function is to the macro level, like you'd get in a hospital scan... It's a phenomenal amount of work to achieve this".
Since the hippocampus is at the core of the brain's learning and memory systems, this finding partly explains the memory-boosting effects of improved cardiovascular fitness.
The core of emotional brain activity seems to be the limbic forebrain: the thalamus, the hypothalamus, the reticular formation, and the amygdala, all of which are subcortical (below the cerebral cortex).
