Sentence examples for core negative regulator from inspiring English sources
At first, the CACGTG-type E-box element and its related sequences in the promoter region of XtPer1 were examined as a plausible core negative regulator in the circadian molecular loop [8].
At the molecular level, its core function as a dominant negative regulator of bHLH activity is conserved with its other three family members (Id1, Id2 and Id3).
Since their discovery 15 years ago, CRY proteins have been acknowledged as a key negative regulator of the core circadian feedback loop.
For example, A20 has been identified as a negative regulator of the core cross-talk element TRAF6 [ 75], and several studies have shown that deficiencies in A20 are associated with some autoimmune diseases, including rheumatoid arthritis [ 76], systemic lupus erythematosus [ 77], and Crohn's disease [ 78].
Conversely, the negative regulator GSK3β was down-regulated.
In this study, we used the p53 and pRb negative bladder cancer cell line 5637 to provide evidence that mdm2 interacts with the hTR core promoter in vivo (figure 1) and serves as a negative regulator of the hTR gene promoter in vitro (figure 2).
As a negative regulator of the Wnt signaling pathway, APC is a core component of the degradation complex that mediates the turnover of β-catenin.
The induction of autophagy in MCF-7 cells occurred upstream of the negative regulator of autophagy MTORC1, and autophagosome formation was dependent on the known core autophagy molecule ATG7 and the IFNB1 signaling molecule STAT1.
Many cis-elements required for constitutive expression are located around the core promoter region, including a 38-bp poly dA-dT) between poly dA-dT−146 and −186 which act as a positive regulator, and eight tandemly repeated copies of imperfect pentamer motif with consensus 'CCCAA' at −294, acting as a negative regulator.
Myostatin (MSTN) is a negative regulator of skeletal muscle mass.
Spl11 encodes an E3 ubiquitin ligase that functions as a negative regulator of programmed cell death.
