Figure 9 Accuracy for the core method in the random pitch dataset adjusting the individual parameters.
Meanwhile, Rajib Ghosh Chaudhuri et al. [40] reported an easy and novel route for the synthesis of hollow Ag2S particles by a sacrificial core method in surfactant containing aqueous media.
The approximate Riemann solver of Roe, which is frequently used as the core method in such legacy codes, is shown to need much user care when adopted as the discretisation scheme for large eddy simulation.
However, we performed a sensitivity analysis to assess anticipated Q-TWiST differences across of range of possible utilities – an approach that is often used as the core method in Q-TWiST analyses reported in the literature (Gelber et al, 1996; Irish et al, 2005; Konski et al, 2009).
What was apparent was that while core methods repeated in the data (shared experience of e.g. role play; video) there was diversity of approach and combinations of methods, and variance in the level of systemisation adopted.
Once a set of core methods was in place (Fig. 3), the pipeline was automated using R scripts and 54 iterations (to explore each combination of three alternative levels of sample QC, SNP-QC and PC-correction, and two levels of CNV-QC) of the pipeline were run, varying thresholds to attempt to determine the impact on sensitivity and specificity.
The core methods are given in each case.
However, despite these efforts, the reliability of the core methods are still in dispute (e.g., Ljunggren et al., 2003).
Here we review core methods and new tools in the modern genomicist's toolbox at three length scales, ranging from single base pairs to megabase-scale chromosomal domains, and discuss the emerging picture of the 3D genome that these tools have revealed.
New intact soil core methods allow for direct in situ measurements of both N2O and N2, which is especially difficult to measure because of its high background concentration.
