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Furthermore, we speculate that such diversified core machineries might provide a mechanism to help lock down and maintain the functions and identity of differentiated cell types.
It is also important to understand how the core machineries can acquire post-translational modifications and additional protein factors in response to specific cellular conditions or localizations.
We anticipate that further analysis of adult neuronal cell-types as well as other differentiated somatic cells will bring new insights regarding the use of alternative core machineries that regulate gene expression in normal and disease states.
Interestingly, this result indicates that upon Myc activation, subunits of both the transcription and translation core machineries (the RNA-PolII and ribosome complexes) are coordinately induced at the layers of mRNA expression and translational efficiency.
The relationship between duplication and ortholog sequence evolution also seems to be at odds with the fact that a considerable number of essential proteins, e.g., components of the core machineries of translation and transcription, do not have any paralogs but nevertheless evolve slowly.
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Japan's core machinery orders rise 4.8 percent in February.
Japan's core machinery orders fell 2.1percentt in May from a month earlier, a smaller decline than had been expected.
Core machinery orders, a measure of capital spending, dropped 3.6percentt in March from the previous month, the government said today.
Core machinery orders, which exclude shipping and utilities, rose to 1.04 trillion yen $9.4 billionn), the highest since November of 2000, from 997 billion yen.
Core machinery orders to Japanese manufacturers rose in January to 991.72 billion yen, or $9.3 billion, up 0.8percentt from December, the Economic Planning Agency said.
Japan's core machinery orders fell 15.6percentt in January, their biggest drop in nearly 15 years, raising fears that slowing business investment will handicap attempts to end a recession.
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