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TOC1 (timing of CAB expression 1) is known to function in the core loop of the clock and controls a suite of clock genes and clock output genes [ 35].
In Arabidopsis, the core loop of the circadian clock is composed of the transcription factors Circadian Clock Associated 1 (CCand and Late Elongated Hypocotyl (LHY), which are positively regulated by Timing of Cab Expression 1 (TOC1) and CCA1 Hiking Expedition (CHE) (McClung 2006, 2010; Pruneda-Paz and Kay 2010).
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The core loop consists of two single MYB transcription factors, Circadian Clock Associated 1 (CCand and Late Elongated Hypocotyl (LHY), which repress the expression of evening-phased pseudoresponse regulator (PRR) and Timing of CAB Expression 1 (TOC1) [ 26– 30].
"I'm looking for a fun core-loop of what you're doing for thirty seconds over and over again," he told me.
A core loop is comprised of the clock genes Per1, Per2, Cry1, and Cry2, which are positively regulated by heterodimers of BMAL1 and CLOCK and negatively regulated by hetero- and homodimers of PER and CRY proteins.
But it struggles to hold onto that feeling as firmly as the first game, diluting the purity of its compelling core loop with an endless parade of under-developed ideas.
It is seen that the cut core loop in the induction range of 0 T ≤ B ≤ 0.8 T has a rounded shape while the new core, made of the ribbon with induced transverse anisotropy, is characterized by much higher linearity of remagnetization loop, which means independence of the core effective permeability on magnetic field.
The positive limb of the core loop is formed by the transcription factors CLOCK and BMAL1.
Two nuclear receptors that are expressed in a circadian pattern modulate the activity of this core loop.
In one of the loops (core loop), the two transcription factors BMAL1 and CLOCK form a complex that binds to specific regions of DNA called enhancer-boxes (E-boxes).
In Arabidopsis, the central oscillator consists of three interlocked transcriptional feedback loops, the core loop, the morning loop, and the evening loop.
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