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The results of our studies suggested that deformation pattern was mainly controlled by processes associated with a linking-damage zone at a fault tip, development of a fault core, localization and channelling of fluids within the fault zone.
Using polyclonal antisera directed at Topoisomerase IIα, we reproducibly observed this staining pattern (core localization and intense staining at the centromere region) in almost 90% of the control cells (Fig. 6F,G, J).
The C-terminal extension contains a functional nuclear core localization (NLS) domain and several binding sites for interaction partners such as BRCA1 and HCFC1.
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Since lipid droplets have been shown to be involved in an important cytoplasmic organelle for HCV production [4], we performed immunofluorescence and confocal microscopic analyses to determine whether or not HCV Core misses localization into lipid droplets in the ESCRT knockdown cells.
This correlates with active PCP signaling and initial asymmetric core component localization (Vladar et al., 2012).
Therefore, it does not appear that Fz/Dsh migration along the reoriented MTs is determining Core protein localization.
This correlates with active PCP signaling and initial asymmetric core component localization (Vladar et al., 2012)." "(A-G) LSM of ALI culture of FltpZV mTECs.
We show that, in addition to Fz, vesicles containing Dsh are transcytosed on these MTs, and that transcytosis is disrupted in ft or ds mutant tissue, suggesting that this trafficking provides directional bias for core protein localization.
Significant progress has been made in understanding the asymmetric core PCP localization in vertebrates but it is less clear how this regulates cytoskeletal rearrangements that drive morphogenesis via tissue specific downstream effector molecules (Wallingford, 2012).
In addition to needle localization, core biopsy and vacuum-assisted core biopsies are currently being performed under magnetic resonance guidance at centers around the world.
Thus, Myosin10/11/14/9 in the notochord appears to localize in the absence of core PCP protein localization, similar to the situation for the atypical myosin Dachs in Drosophila, which is also polarized independently of the core PCP pathway (Brittle et al., 2012).
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