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Motif G (653- RYMI in LACV, 658- RKLL in influenza PA) is in helix α24 in the core-lobe of the PA-C like domain, the conserved arginine being positioned to interact with the priming NTP.
The thumb domain is surrounded by the PA-C like domain core lobe and a set of helices (α58 62 and α67) and strands (β31 34), denoted the thumb ring which is structurally homologous to the influenza PB2 N1 and N2 domains.
The larger "core-lobe" is α-helical and buttresses the thumb and palm domains of the RdRp.
In addition, we compute the binding energies of an Re solute atom to the cores of 1/2⟨111⟩ screw and edge dislocations, and find the binding energy to be highest in the tensile lobe of the edge core.
Thus the "WC" motif couples two ROPK-specific inserts to the substrate-binding lobe of the kinase core.
A 1 cm core sample was extracted from the visually estimated center of the left upper lobe of the lung, fixed in 4% buffered formalin and embedded in paraffin.
Biopsy specimens were obtained from the parenchyma of segment 6 in the right lobe of the liver with an 18-gauge core biopsy needle (Bard MaxCore Disposable Core Biopsy Instrument, Tempe, AZ, USA) under ultrasound guidance.
In addition to a kidney and lobe of a liver, living donors can give the lobe of a lung and bone marrow.
Each lobe bonds with a lobe of a neighboring carbon atom, forming a honeycomb pattern that looks like a piece of chicken wire.
Suddenly, the lobe of my brain that held all my pain plunged into darkness and the lobe that held my anger blazed with light.
Lobe-by-lobe QSAR correlation plots revealed a single lobe of the LUMO to be strongly associated with tryptanthrin's anti-malarial activity.
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