Thus, a core limitation with the dosing region model of medication ordering is that it is not practical to develop a dosing region for every conceivable scenario of pediatric drug dosing.
According to Heesink et al. (1993), three extreme types of conversion behaviour are distinguished: core reaction limitation, product-layer diffusion limitation and grain reaction limitation.
Because of the disease's chronicity and the often severe core activity limitations it causes, COPD patients usually require a high level of caregiving.
The high prevalence, chronicity and frequent exacerbations of COPD cause frequent emergency room visits, hospitalizations, disability (severe core activity limitations) and death.
While the chelates and CuAAC strategies used here are expected to be generally applicable for labeling biomolecules with the fac-[MI CO 3]+ core, several limitations are worth noting.
Additionally, severe or core activity limitations often presenting in the mentally ill (Australian Bureau of Statistics 2006) can determine their degree of dependence and be a contributing factor to heat susceptibility (Davido et al. 2006).
Stoichioproteomics derives a number of specific hypotheses from a single core precept: that limitation in an element leads to purifying selection in order to reduce the usage of amino acids needing that element in protein sequences or their expression.
NEW YORK TIMES Inside Avon's Fall | Under the longtime chief executive Andrea Jung, Avon "strayed from its core without realizing the limitations that came with its direct-selling channel and customers," Fortune reports.
"It's a good deal – a deal that meets our core objectives, including strict limitations on Iran's program and cutting off every pathway that Iran could take to develop a nuclear weapon".
