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Thus, although kinetochores do contain limited H3K9me3-containing chromatin regions (Ribeiro et al, 2010), the CENP-A chromatin core in the active kinetochore must be protected from Suv39h1-induced H3K9 tri-methylation during mitotic exit.
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By selectively removing its autoinhibitory C-terminus, we determine the first crystal structure of the Snf7 core domain in the active conformation at 1.6 Å resolution.
Crystallographic and spectroscopic studies have shown that these enzymes share a common 2-His/4-carboxylate ligand set where the diiron core in the biferrous active site is weakly magnetically coupled through two μ-1,3-carboxylate bridges.
We found that (1) the V67L mutation lowers the global fluctuations in all modeled mini-inteins, stabilizing the mini-intein constructs; (2) the connecting linker length affects intein dynamics; and (3) the flexibilities of the linker and intein core are higher in the active structure.
Later on, a main source of emission was located in the core of the active region, which is an indirect signature of the magnetic reconnection occurring behind the erupting flux rope.
Each of these systems was made of two parts: (1) the conveyor system made of SPHC which is used for keeping the dosage form at specific site(s) of the GI tract by mechanical interaction of the dosage form with the intestinal membranes, and (2) the core containing the active ingredient and incorporated in the conveyor system.
The NMR measurements used the four methionine residues in AlkB as spectroscopic probes, because residues M49 and M57 in the nucleotide recognition lid (NRL) domain and M61 in the dioxygenase core domain are located in the active site in the AlkB/Fe(II)/2OG/5′-TmAT-3′ (mA = 1-methyl A) complex structure.
An increase in the number of hydrophobic atoms in the active core of drug -target interface further increases the biological activity of the drug lead.
Alanine replacements in the C-terminal hexapeptide (YFTPRLamide) revealed the relative importance of each residue in the active core as follows: R5 > L6 > F2 ≫ P4 > T3 ≫ Y1.
The cross-sectional view of transmission electron microscopy (TEM) images of a portion of the 30-period QDCL shown in Figure 2a,b gives the direct and clear evidences of distinct coupled QDs layers in the active core.
This heat load is the result of several different processes, namely resistance losses due to DC resistance and proximity effects, ferrite core losses and switching losses in the active semiconductor switching components.
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