Amyloid deposits and neurofibrillary tangles formation are the core pathological hallmarks of Alzheimer's disease (AD) [ 1].
Pathological signaling has been also studied and two core pathological hallmarks of AD, amyloid plaques and neurofibrillary tangles (NFT) accumulation, have been elucidated intensively.
Inflammatory microenvironment can supply survival factors, growth factors, pro-angiogenic factors and other hallmark-facilitating factors to promote the acquisition of many core hallmark capabilities [ 2, 43].
This trial showed marked reduction in Rbm fragmentation (core structural hallmark of EMT), epidermal growth factor receptor (EGFR), basal epithelial cell S100A4 expression and in Rbm cell S100A4 and MMP-9 in the active inhaled corticosteroids (ICS) compared to placebo [23].
He is shedding some of its core steel businesses, the hallmarks of Thyssen and Krupp, two giants which merged in 1999.
The Ryr1 AG/+ mutant mouse muscles have decreased intracellular calcium, core-like structures and decreased ATP content, as well as other ultrastructural hallmarks of core-like diseases.
First, we identified a mutation in RyR1 that induces a myopathy with ultrastructural hallmarks of cores similar to the Ryr1 I4895T/+ mutant mouse, a known mouse model of CCD (Boncompagni et al., 2009, 2010).
Because the clustering technique is unsupervised we can conclude that the profile that emerges from this clustering technique is indeed one of the hallmarks of the core promoter.
Reviewer # 3: The authors have identified a mutation in RyR1 that shows hallmarks of central core disease (e.g. muscle weakness).
The hydrophobic core is a hallmark of transmembrane proteins hence a method that considers the hydrophobicity of residues is a better classifier of these structures.
