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Extended Data Fig. 3 Computation of ovary-specific and pan-cancer core fitness genes with ADaM, and a summary of context-specific and core fitness genes.
a, The 553 pan-cancer core fitness genes in reference essential gene sets are shown9,10.
Extended Data Fig. 4 Characterization of ADaM pan-cancer core fitness genes.
The 132 newly identified core fitness genes fall outside of these reference gene sets.
"It comes from overuse, it comes from bad technique and it comes from a lack of core fitness.
The x coordinate estimates the minimal number of cancer types k∗ for which a gene should have been predicted as a cancer-type-specific core fitness gene in order to be classified as a pan-cancer core fitness gene.
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We have analyzed two of the primary forms of genomic conflicts, genomic imprinting (parental antagonism) and sexual antagonism, because they both predict conflict-driven, health-related deviations from optimal phenotypes for one or both of the parties involved, in the core fitness-related domains of parent offspring and male female interactions, respectively.
There is a huge population of women who are interested in fitness, but a much smaller number of hard-core fitness enthusiasts who are interested in reading about sports".
Some of the lab's equipment might be familiar to elite athletes and hard-core fitness enthusiasts.
Friends have complained of debilitating shoulder pain from working too many hours at the computer, from overdoing it at yoga or from jumping too fast into a hard-core fitness program.
While the Palos Verdes classes are filled with a fair number of retirees who take it at their own pace, the routine itself provides good cross-training for even hard-core fitness fans, thanks to the nonstop resistance provided by the water.
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