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Overall only a few of these genes follow the bursting trend of the RNA polymerases, notably, among them, SPT15, which forms the TATA-binding protein and is also a component of the polymerase I core factor and of TFIIIB.
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The knowledge scope with regards to core factors and thresholds are solved.
This clearly reveals that these two families of enzymes work as core factors and that GHF10, 11 and 45 help these core factors for the efficient cellulose degradation of the lower termite.
Therefore, the top miRNAs indirectly target the core factors and indirectly regulate the pluripotency.
This result parallels with recent experimental observations showing that miRNAs repress the pluripotent core factors and pluripotency during differentiation [ 16].
This direct linkage between up-regulated miRNAs and down-regulated core factors suggested that these miRNAs directly inhibit the pluripotent core factors and repress pluripotency to facilitate differentiation during stem cell differentiation.
Myc has more target genes than any of the core factors, and its target genes show unique histone modification marks in their promoters.
Courbard, J.R., Djiane, A., Wu, J. & Mlodzik, M. The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors.
Recruitment of RNA Pol I to the rDNA promoter involves four transcription factors, including the upstream activating factor (UAF) complex, TATA-binding protein (TBP), core factor (CF) complex and Rrn3 [ 40].
Transcription initiation at the ribosomal RNA promoter requires RNA polymerase (Pol) I and the initiation factors Rrn3 and core factor (CF).
However, it appears that the actual core factor set regulating pluripotency and early differentiation in ES cells is larger and more highly interconnected than previously suspected.
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