Sentence examples for core defects that from inspiring English sources

Thus, these lipotoxic molecules antagonize the core defects that characterize T2DM.

The results of the current study demonstrate that, in Mexican Americans, subjects with HbA1c = 6.0% already manifest severe forms of both core defects that are characteristic of type 2 diabetes, i.e., insulin resistance (44% decrease in insulin sensitivity) and β-cell dysfunction (62% decrease in IS/IR index).

Despite the complexities of this clinical picture, the pathophysiological defects underlying T2DM can be attributed in large part to a single core defect, that is, inappropriate resistance to the biologic effects of insulin [ 1, 2].

A core of apoptotic tissue characterized the granulation tissue of 150K-treated defects, that covered a larger area than both 40K and 10K-treated defects (p=0.0417, p=0.0515, respectively, Figure  7A, B).

So, these are the defects that will destroy us.

There were 13 eyes with localized RNFL defects that had 1 LC defect, 1 eye with 2 LC defects, and 1eye with 3 LC defects.

Pioglitazone is unique in that it both exerts β-cell protective effects (81) and is a powerful insulin sensitizer in muscle and liver (56– 65, 65, 74– 76) Thus, it is the only antidiabetes agent that corrects the core defects of insulin resistance and β-cell failure in T2DM.

Ro 04-6790 also reversed impairment in learning consolidation produced by the NMDA receptor antagonist MK-801, and the antagonist PRX-07034 restored the impairment of novel object recognition in the social isolation rearing model, both of which showed behavioral changes that resemble the core defects observed in schizophrenia [ 11].

The only molecular defects that we could provide evidence for in PIASγ-depleted cells were the inability to remove centromeric catenations and a lack of Topoisomerase II localization to centromere regions (and mitotic chromosome cores in some cells).

This suggests that the reason for the device degradation after vacuum annealing at 300 °C is related to a defect that is not directly probed by core-level XPS.

It is that structural defect that is fundamental".