Sentence examples for core defects of from inspiring English sources

New York, NY (November 21 , 2013 – A single overactive enzyme worsens the two core defects of diabetes impaired insulin sensitivity and overproduction of glucose suggesting that a drug targeting the enzyme could help correct both at once, according to mouse studies done by researchers at Columbia University Medical Center.

Although antidiabetic agents have been developed to target one or more of the core defects of type 2 diabetes mellitus (T2DM), many patients do not achieve glycemic goals.

The core defects of T2DM include quantitative and qualitative β-cell dysfunction, peripheral (skeletal muscle) insulin resistance, and elevated glucose production in the liver, as well as increased lipolysis when obesity is present.

In summary, the results of the current study demonstrate that Mexican American subjects with HbA1c >6% manifest both core defects of type 2 diabetes in severe form (44 and 74% decrease in insulin sensitivity and β-cell function, respectively).

Experimental NEFA elevation to reproduce levels in type 2 diabetes causes severe muscle/liver insulin resistance [ 133– 135] and inhibits insulin secretion [ 136], reproducing the three basic core defects of type 2 diabetes.

The harmful metabolic effects of chronic hyperglycemia associated with the two core defects of T2DM, insulin resistance and partial β-cell failure, can be described as "glucose toxicity", which contributes in turn to further progression of β-cell dysfunction in a vicious cycle of glucose toxicity-induced pathogenesis [ 11, 12].

This function allows the changes to be visualized as a 2D image of belt core defects on all belt sections and splices.

Every Justice wrote an opinion but the core defect of arbitrariness was aptly captured by Justice Potter Stewart's claim that receiving a death sentence was like being struck by lightening.

The results of the current study demonstrate that, in Mexican Americans, subjects with HbA1c = 6.0% already manifest severe forms of both core defects that are characteristic of type 2 diabetes, i.e., insulin resistance (44% decrease in insulin sensitivity) and β-cell dysfunction (62% decrease in IS/IR index).

Of the core defects in T2DM (20), pioglitazone improved both the MI of SI and the insulin secretion/insulin resistance (disposition) index, which represents the gold standard for β-cell function (Fig. 4).

Early testimony by doctors powerfully underscored the law's core defects -- namely, the glaring absence of an adequate exception to protect a woman's health and its astonishingly broad reach.