Sentence examples for core death from inspiring English sources

The first is a cell-autonomous mechanism, in which kri-1 regulates the core death pathway (EGL-1 or CED-9) in germ cells to initiate cell death.

Although this may reflect incomplete ablation of the autophagy pathway by autophagy gene knockdown, it is also possible that autophagy proteins do not function in the core death machinery of autosis.

50% of these siRNAs significantly reduced the sensitivity of cells to TRAIL-induced cell death, including 5/5 core death pathway genes (BID, CASP3, CASP8, DIABLO and TNFRSF10A, Figure 1).

Because kri-1 functindependentlyently of cep-1 and impinges on the core death pathway, we were interested to know whether kri-1 is cooperating with other genes known to regulate germ cell death independently or downstream of cep-1.

The data above suggest a model wherein kri-1 functions downstream of or in parallel to the key decision-making step in the cell death pathway and likely regulates components of the core death pathway (i.e., egl-1, ced-9, ced-4, and ced-3).

In cancer cells, anti-apoptotic factors such as the Inhibitors of Apoptosis (IAPs) render cells resistant to apoptosis, primarily through their inhibition of core death executioners, the caspases, or through the neutralization of antagonists such as Smac/DIABLO and Omi/HtrA2 [ 1].

We focus here on the core outcome "death at latest follow-up" (death during the first week in three studies and death during the first four weeks in one study; in the remaining study it was not assessed, so we exclude this study).

Many questions remain, such as how adjacent cells respond to the necrotic infarct core, what death signals are released to spread death, and whether there are genetic pathways regulating cell death.

These underly numerous anti-cancer strategies targeting components of the core cell death machinery to promote tumor cell death [21], [22].

The pageant came 15 years after an episode that shook the monarchy to its core: the death of Princess Diana in a car crash in Paris, and the surge of popular opprobrium that had crowds demanding to know why Elizabeth remained in Scotland with Diana's two sons, refusing, until the prime minister insisted, to join in the outpouring of public grief in London.

Prosurvival mechanisms can operate at mitochondrial and postmitochondrial levels to attenuate core apoptotic death program.