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The clear shortcoming of the core constraint is that at some level of divergence, core regions cannot be aligned correctly without insertions or deletions, hence methods without the core constraint are more suited to remote homolog recognition and alignment.
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The core constraint may be incorporated into other alignment algorithms as well.
Constraint is our friend.
The constraint is important.
The constraint is our brain.
"The constraint is supply.
Another constraint is simply culture.
"The constraint is actually time.
Mission constraint is a unifier.
Constraint is a unifier".
An ACL profile is composed of a core constraint language, which is shared with the other profiles, and a MOF architecture metamodel.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com